PhD student 15 – Evaluating the endosomal transport and efficacy of therapeutics for metabolic liver diseases progressing to cancer
InteRNA technologies, Utrecht, NL
Roel Schaapveld, schaapveld[at]interna-technologies.com
You are employed and the research is done at InteRNA. In addition, you are registered at the Utrecht University, NL, where you will do the thesis defence.
The PhD student will study the endo-lysosomal trafficking of therapeutics by monitoring the fate of fluorescent labelled therapeutics, such as lipid nanoparticle-coupled miRNAs or guided RNAs for CRISPR-based approaches.
The role of endo-lysosomal network on the fate of therapeutics by inhibiting key regulators of endo-lysosomal transport will be explored and will determine the impact of altering endo-lysosomal transport on the treatment efficacy of novel RNA-based therapeutics in mouse models of diseases, such as liver cancer.