PhD student 9 – Transcriptional regulation and functional validation of endo-lysosomal genes in metabolic diseases
Nebion, Zurich, CH
Philip Zimmermann, phz[at]nebion.com
You are employed and the research is done at Nebion. In addition, you are registered at the Helmholtz Institute, Munich, Germany, where you will do the thesis defence
The PhD student will scout and curate public transcriptomic datasets of healthy, diseased and treated patient samples and mouse models of NAFLD/NASH with focus on liver and adipose tissue. The student will be involved in the integration of the datasets and meta-analysis to gather insights for follow-up experimental planning with emphasis on endo-lysosomal processes. Perturbation analysis will be performed to formulate the potential role of top candidates in metabolic disease. After prioritization, several candidates will be further studied in cellular and mouse models.