PhD student 5 – Coordination of endo-lysosomal cargo transport by NPC1 and post-NPC1 regulators of lipid metabolism
University of Helsinki, FI
Elina Ikonen, elina.ikonen[at]helsinki.fi
The PhD student will investigate how trafficking of NPC1 is regulated by endosomal machineries and how this will impact endo-lysosomal lipid delivery to post-NPC1 destinations, including the plasma membrane, ER and lipid droplets. The student will take advantage of advanced live cell imaging techniques to visualize lipids and proteins and dissect how proteins coordinate cellular lipid deposition between endo-lysosomes and lipid droplets, with relevance to lysosomal storage and fatty liver diseases.