PhD student 3 – Understanding the fate of cargo via ubiquitination by E3 ligases and its role in hepatic function
AstraZeneca, Cambridge, UK
Helen Boyd, helen.boyd[at]strazeneca.com
Kevin Moreau, kevin.moreau[at]atrazeneca.com
You are employed and the research is done at AstraZeneca. In addition, you are registered at the University of Amsterdam (AMC), the Netherlands where you will do the thesis defence.
The PhD student will investigate the role of sorting proteins in hepatic function and identify the molecular mechanisms that induce specific stimulated degradation of endo-lysosomal proteins. The student will develop technology for down regulation of receptors and transporters via targeted protein degradation and investigate the expression profile of E3 ligases involved in glucose and lipid metabolism.