PhD student 4 – Uncovering the spatio-temporal regulation of endo-lysosomal lipid trafficking in control of metabolism

University Medical Centre Utrecht, NL
Judith Klumperman, j.klumperman[at]umcutrecht.nl

The PhD student will establish the role of Vps3, Vps8 and Vps33B in cholesterol and LDLR/LRP1 transport and whether the SNX17 retriever CCC complex exit from early endosomes sorts cargo into Vps3/8/33B dependent transport vesicles. The student will be involved in characterizing the compartments and mechanisms involved in segregation of cholesterol/Rab8/CD63 positive carriers from LAMP-positive lysosomes.

Link to vacancy


PhD student 6 – Genome-wide functional genetic approaches to identify novel regulators of the endo-lysosomal network in control of lipid metabolism.

Amsterdam Medical Centre, NL
Noam Zelcer, n.zelcer[at]amsterdamumc.nl

The PhD student will develop and use mammalian haploid- and CRISPR-Cas9-based genome-wide genetic screens to interrogate regulation of endogenously tagged proteins involved in intracellular trafficking of cholesterol within the endo-lysosomal network and in delivery of lipoprotein-derived cholesterol to the ER/lipid droplets. Identified regulators will be studied using cellular and mouse models, and the metabolic consequence of their hepatic-specific deficiency on lipid and energy metabolism in atherosclerosis and metabolic syndrome will be investigated.

Link to vacancy


PhD student 9 – Transcriptional regulation and functional validation of endo-lysosomal genes in metabolic diseases.

Nebion, Zurich, CH
Philip Zimmermann, phz[at]nebion.com

You are employed and the research is done at Nebion. In addition, you are registered at the Helmholtz Institute, Munich, Germany, where you will do the thesis defence

The PhD student will scout and curate public transcriptomic datasets of healthy, diseased and treated patient samples and mouse models of NAFLD/NASH with focus on liver and adipose tissue. The student will be involved in the integration of the datasets and meta-analysis to gather insights for follow-up experimental planning with emphasis on endo-lysosomal processes. Perturbation analysis will be performed to formulate the potential role of top candidates in metabolic disease. After prioritization, several candidates will be further studied in cellular and mouse models.

Link to vacancy will follow soon.


Important note for candidates:

Eligible candidates for a PhD position in the EndoConnect training network should have the following qualifications:

  • A(n) (almost) completed master’s degree in a discipline relevant to the PhD position(s) for which you apply.
  • Strong motivation for scientific research in an interdisciplinary and international environment
  • Excellent English presentation and writing skills
  • Good organizational and communication skills, being a team-player

Successful candidates must fulfil the criteria defined by the European Commission:

  • As an Early Stage Researcher, you have to be in the first four years of your research career and have not been awarded a doctoral degree at the time of recruitment.
  • At the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to the reference date.