Publications •

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Andries Heida, Theo van Dijk, Marieke Smit, Martijn Koehorst, Mirjam Koster, Niels Kloosterhuis, Rick Havinga, Vincent W. Bloks, Justina C. Wolters, Alain de Bruin, Jan Albert Kuivenhoven, Jan Freark de Boer, Folkert Kuipers, Bart van de Sluis

The Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex is a pentameric [read more…]

December 20, 2023|Categories: Publications|Tags: , |

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg, Bahar Najafi, Surui Wang, Anna-Luisa Warnke, Susanne Seitz, Daniela Hass, Sofiya Gancheva, Sabine Kahl, Bin Yang, Brian Finan, Kathrin Schwarz, Juergen G Okun, Michael Roden, Matthias Blüher, Timo D Müller, Natalie Krahmer, Christian Behrends, Oliver Plettenburg, Marta Miaczynska, Stephan Herzig, [read more…]

July 13, 2023|Categories: Publications|

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. [read more…]

July 13, 2023|Categories: Publications|

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Michael D. Healy, Kerrie E. McNally, Rebeka Butkovič, Molly Chilton, Kohji Kato, Joanna Sacharz, Calum McConville, Edmund R.R. Moody, Shrestha Shaw, Vicente J. Planelles-Herrero, Sathish K.N. Yadav, Jennifer Ross, Ufuk Borucu, Catherine S. Palmer, Kai-En Chen, Tristan I. Croll, Ryan J. Hall, Nikeisha J. Caruana, Rajesh Ghai, Thi H.D. Nguyen, [read more…]

July 13, 2023|Categories: Publications|

Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins

Dyonne Y. Vos, Melinde Wijers, Marieke Smit, Nicolette Huijkman, Niels J. Kloosterhuis, Justina C. Wolters, Joël J. Tissink, Amanda C.M. Pronk, Sander Kooijman, Patrick C.N. Rensen, Jan Albert Kuivenhoven and Bart van de Sluis

The coiled-coil domain containing 22/coiled-coil domain containing [read more…]

November 21, 2022|Categories: Publications|Tags: , , , , , , |

Endosomal trafficking in metabolic homeostasis and diseases

Jerome Gilleron and Anja Zeigerer

Abstract | The global prevalences of obesity and type 2 diabetes mellitus have reached epidemic status, presenting a heavy burden on society. It is therefore essential to find novel mechanisms and targets that could be utilized in potential treatment strategies and, as [read more…]

October 12, 2022|Categories: Publications|Tags: , , , |

Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation

Camilla Ruffilli, Sascha Roth, Monica Rodrigo, Helen Boyd, Noam Zelcer, and Kevin Moreau

ABSTRACT: Targeted protein degradation (TPD) is a promising therapeutic modality to modulate protein levels and its application promises to reduce the “undruggable” proteome. Among TPD strategies, Proteolysis TArgeting Chimera (PROTAC) technology has shown a tremendous potential [read more…]

September 21, 2022|Categories: Publications|Tags: , , , , , |

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease

Tamara Marín1, Andrés E. Dulcey2, Fabián Campos1, Catalina de la Fuente3, Mariana Acuña1,4, Juan Castro1, Claudio Pinto3, María José Yañez5, Cristian Cortez6, David W. McGrath7, Pablo J. Sáez7, Kirill Gorshkov2, Wei Zheng2, Noel Southall2, Maria Carmo-Fonseca8, Juan Marugán2*, Alejandra R. Alvarez3* and Silvana Zanlungo1*

Niemann-Pick type A (NPA) disease [read more…]

Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)

Dyonne Y. Vos, Bart van de Sluis

Background: Metabolic-associated fattyliverdisease (MAFLD), also known as non-alcoholic fatty liver disease, has become the leading cause of chronic liver disease worldwide. In addition to hepatic accumulation of triglycerides, dysregulated cholesterol metabolism is [read more…]

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