Publications •
Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation
Camilla Ruffilli, Sascha Roth, Monica Rodrigo, Helen Boyd, Noam Zelcer, and Kevin Moreau
ABSTRACT: Targeted protein degradation (TPD) is a promising therapeutic modality to modulate protein levels and its application promises to reduce the “undruggable” proteome. Among TPD strategies, Proteolysis TArgeting Chimera (PROTAC) technology has shown a tremendous potential [read more…]
c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease
Tamara Marín1, Andrés E. Dulcey2, Fabián Campos1, Catalina de la Fuente3, Mariana Acuña1,4, Juan Castro1, Claudio Pinto3, María José Yañez5, Cristian Cortez6, David W. McGrath7, Pablo J. Sáez7, Kirill Gorshkov2, Wei Zheng2, Noel Southall2, Maria Carmo-Fonseca8, Juan Marugán2*, Alejandra R. Alvarez3* and Silvana Zanlungo1*
Niemann-Pick type A (NPA) disease [read more…]
Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)
Dyonne Y. Vos, Bart van de Sluis
Background: Metabolic-associated fattyliverdisease (MAFLD), also known as non-alcoholic fatty liver disease, has become the leading cause of chronic liver disease worldwide. In addition to hepatic accumulation of triglycerides, dysregulated cholesterol metabolism is [read more…]